Peer-reviewed veterinary case report
Dog with amantadine overdose treated successfully with IV lipid
By Hogberg, Brett et al.·Published in Veterinary Medicine and Science·2025·Ocean State Veterinary Specialist East Greenwich Rhode Island USA, United States·View original on Crossref →
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Original publication title: Successful Treatment With Intravenous Lipid Emulsion of Accidental Amantadine Overdose: A Case Report
Plain-English summary
A 2.5-year-old Chinese Crested accidentally received a very high dose of amantadine, which caused symptoms like tremors, agitation, and eye problems. After trying another medication without success, the veterinarian started treatment with intravenous lipid emulsion therapy. This treatment worked well, and all the dog's symptoms disappeared, with the dog remaining healthy during follow-up checks over the next several weeks. This case shows that intravenous lipid emulsion can be an effective way to treat amantadine overdose in pets.
People also search for: dog amantadine overdose treatment · Chinese Crested tremors · intravenous lipid emulsion for dog toxicity
Abstract
ABSTRACT A 2.5‐year‐old, 4.9 kg, Chinese Crested was accidentally administered a dose of 43.5 mg/kg of amantadine, resulting in the rapid onset of tremors, agitation, vertical nystagmus, and lack of pupillary light reflex in one eye. After unsuccessful treatment with methocarbamol, a 1.5 mL/kg bolus of 20% intravenous lipid emulsion therapy was initiated followed by a 0.25 mL/kg/min continuous rate infusion. All clinical signs secondary to the amantadine toxicity resolved following intravenous lipid emulsion therapy and remained normal on 24 h, day 5, day 18, and day 50. This represents the first report of amantadine toxicity in a clinical setting and is the first case showing that intravenous lipid emulsion therapy could be an effective treatment for amantadine toxicity.
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Search related cases →Original publication on Crossref: https://doi.org/10.1002/vms3.70402