Peer-reviewed veterinary case report
Heat-killed EB-AMDK19 helps reduce diet weight gain in beagles
By Hong, Moon-Gi et al.·Published in Archives of animal nutrition·2024·R&D Center, South Korea·View original on PubMed →
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Original publication title: Supplementation with heat-killedEB-AMDK19 counteracts diet-induced overweight in beagles.
- Species:
- dog
Plain-English summary
A group of beagles was fed a high-fat diet for 12 weeks and showed signs of weight gain and increased body fat. To help manage their weight, the dogs were given a dietary supplement made from heat-killed bacteria called AMDK19-HK. This supplement successfully prevented further weight gain and fat accumulation, while also improving the balance of bacteria in their gut. The beagles did not show significant changes in other health markers, but the results suggest that AMDK19-HK could be a helpful option for dogs struggling with obesity.
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Abstract
Obesity is a major health problem in dogs and is strongly associated with an increased risk of chronic inflammatory and metabolic diseases. The microaerophilic human gut bacteriumhas been proposed as a potential preventive and therapeutic agent against obesity in both humans and mice; however, the protective effects of human-derivedagainst canine obesity remain unstudied. We previously demonstrated that the heat-killedstrain EB-AMDK19 (AMDK19-HK) isolated from the faeces of a healthy Korean exerts similar protective effects as the live bacterium in mice with high-fat-diet (HFD)-induced obesity. Here, we evaluated the effects of AMDK19-HK on body weight, body fat mass, haematological and biochemical parameters, and faecal microbiota composition in beagles fed an HFD for 12 weeks. AMDK19-HK supplementation effectively suppressed body weight increase, body fat deposition and serum triglyceride increase in the canine model; however, no significant changes in the overall haematological and biochemical parameters were observed, reflecting the direct anti-obesity effect of AMDK19-HK. Additionally, 16S rRNA gene sequencing revealed that AMDK19-HK supplementation induced significant changes in the faecal bacterial community, with an increased abundance ofand a decreased abundance of. These results suggest that AMDK19-HK can be used as a dietary supplement to counteract diet-induced overweight in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39264284/