Peer-reviewed veterinary case report
Suspect novel adverse drug reactions to trimethoprim-sulphonamide combinations in horses: a case series.
- Journal:
- Equine veterinary journal
- Year:
- 2011
- Authors:
- Stack, A & Schott, H C
- Affiliation:
- Department of Large Animal Clinical Sciences · United States
- Species:
- horse
Plain-English summary
In this study, researchers looked at five horses that had unusual reactions to a common antibiotic combination called trimethoprim-sulphonamide. Four of the horses showed signs like unsteady walking, restlessness, and strange behavior while on the medication, and one foal received too much of the drug. Once the medication was stopped, all the horses returned to normal without any lasting issues. The researchers couldn't find any other reasons for the neurological problems, suggesting that these reactions might be a new side effect of this antibiotic combination. Overall, stopping the medication successfully resolved the symptoms in all the horses.
Abstract
Adverse drug reactions to trimethoprim-sulphonamide combinations are common in many species, manifesting as gastrointestinal tract disorders, dermatopathies and blood dyscrasias. In this case series, neurological abnormalities in 4 horses being treated with trimethoprim-sulphonamide combinations at normal dosages and in one foal that received an overdose are described. The horses developed hypermetric gait, agitation and erratic behaviour. All signs resolved once medication was withdrawn, and no horse had residual deficits. No other cause for observed neurological deficits could be determined. These clinical signs appear to represent a novel adverse drug reaction to some commonly used antimicrobial combinations.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21143643/