Peer-reviewed veterinary case report
Tarantula cubensis extract changes cell death in dog mammary tumors
By Gultiken, Nilgun et al.·Published in Journal of veterinary science·2015·University of Ondokuz Mayis·View original on PubMed →
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Original publication title: Tarantula cubensis extract alters the degree of apoptosis and mitosis in canine mammary adenocarcinomas.
- Species:
- dog
Plain-English summary
Thirteen dogs with mammary tumors were treated with an extract from the Tarantula cubensis to see if it could help control their cancer. The dogs received three injections of the extract over three weeks, and then their tumors were surgically removed. After treatment, the tumors showed signs of increased cell death, which is a positive outcome for managing cancer growth. This suggests that Tarantula cubensis extract could be a helpful option for dogs with mammary adenocarcinoma.
People also search for: dog mammary tumor treatment · Tarantula cubensis for dog cancer · canine adenocarcinoma therapy
Abstract
In the present study, 13 clinical cases of canine mammary adenocarcinoma were evaluated in order to understand the effect of Tarantula cubensis extract (TCE) on tumor tissue. Punch biopsies were taken from the tumors before treatment with TCE. Subcutaneous injections of TCE were administered three times at weekly intervals (3 mL per dog). Between days 7 and 10 after the third injection, the tumor masses were extirpated by complete unilateral mastectomy. Pre- and post-treatment tumor tissues were immunohistochemically assessed. The expression of B-cell lymphoma 2 (Bcl-2) was found to be higher in pre-treatment compared to post-treatment tissues (p < 0.01) whereas Ki-67 expression was lower in post-treatment tissues (p < 0.01). No significant differences in fibroblast growth factor or vascular endothelial growth factor expression were observed between pre- and post-treatment tissues (p > 0.05). The apoptotic index was determined to be low before treatment and increased during treatment. These results suggest that TCE may be effective for controlling the local growth of canine mammary adenocarcinoma by regulating apoptosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25549212/