Peer-reviewed veterinary case report
Testicular enzyme and protein levels in dogs with cryptorchid Sertoli
By Kawakami, Eiichi et al.·Published in The Journal of veterinary medical science·2007·Nippon Veterinary and Life Science University, Japan·View original on PubMed →
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Original publication title: Testicular superoxide dismutase activity, heat shock protein 70 concentration and blood plasma inhibin-alpha concentration of dogs with a Sertoli cell tumor in a unilateral cryptorchid testis.
- Species:
- dog
Plain-English summary
A 5 to 15-year-old dog with a retained testicle (cryptorchidism) was found to have a Sertoli cell tumor, which is a type of testicular cancer. In a study of dogs with testicular tumors, it was noted that Sertoli cell tumors were most common in cryptorchid testes, occurring in 71% of cases. The researchers measured certain substances in the dogs' blood and testicular tissue, finding that those with Sertoli cell tumors had higher levels of heat shock proteins and lower levels of a hormone called inhibin-alpha compared to normal dogs. This suggests that these factors might help identify dogs at risk for developing this type of tumor.
People also search for: dog testicular tumor symptoms · cryptorchid dog treatment · Sertoli cell tumor in dogs
Abstract
The proportions of Sertoli cell tumor (SCT), seminoma and Leydig cell tumor in 50 dogs with unilateral testicular tumors were 52%, 36% and 12%, respectively. The rate of occurrence of SCT in the cryptorchid testis was very high (71%). The testicular superoxide dismutase (SOD) activity, testicular heat shock protein (HSP) 70 concentration and peripheral blood plasma inhibin (INH)-alpha concentration of 10 dogs with a unilateral cryptorchid testis and no testicular tumors, 10 dogs with SCT in a unilateral cryptorchid testis and 10 normal dogs, all aged 5-15 years, were measured in order to identify high risk factors for the occurrence of SCT in the canine cryptorchid testis. The mean SOD activity in cryptorchid testes and SCTs was significantly lower and higher, respectively, than in normal testes (both P<0.01). The mean HSP 70 concentration in both cryptorchid testes and SCTs was significantly higher than in normal testes (both P<0.01). The mean plasma INH-alpha concentration of the cryptorchid and SCT dogs was significantly lower and higher, respectively, than in normal dogs (P<0.05 and 0.01, respectively). The low SOD activity in the cryptorchid testis, low blood plasma INH-alpha concentration of the cryptorchid dogs and high HSP 70 concentration in the SCTs may be related to the occurrence of SCT and tumor cell proliferation in canine cryptorchid testes.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18176022/