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Peer-reviewed veterinary case report

Dog with ovarian tumor containing both liposarcoma and leiomyoma

By Shiwa, Nozomi et al.·Published in The Journal of veterinary medical science·2016·Department of Veterinary Pathology, Japan·View original on PubMed

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Original publication title: The co-existence of a myxoid liposarcoma and leiomyoma in the same ovarian mass of a dog.

Species:
dog

Plain-English summary

A 15-year-old female mixed-breed dog was brought in with a swollen belly, which led to surgery where a large ovarian mass was found. The mass turned out to be a mix of two types of tumors: a myxoid liposarcoma (a type of cancer) and a leiomyoma (a benign tumor). Unfortunately, four months after the surgery to remove the mass, the dog passed away due to cancer spreading to other organs, specifically from the liposarcoma. This case is notable because it’s the first time both types of tumors have been reported together in a dog's ovary.

People also search for: dog ovarian mass symptoms · dog abdominal swelling · dog cancer treatment options

Abstract

A 15-year-old, female mixed-breed dog presented with abdominal distention. An exploratory laparotomy revealed a large left ovarian mass (20 × 15 × 12 cm). Histopathological examination of the mass revealed a mixed myxoid liposarcoma and a well-differentiated leiomyoma. Four months after surgical removal of the mass, the dog died due to multiorgan metastasis. The metastasis was composed solely of the liposarcoma component. The liposarcoma component was Alcian Blue- and Oil red O-positive, and demonstrated immunoreactivity with S-100, adipophilin and vimentin. Electron microscopy revealed that the tumor cell cytoplasms were packed with lipid vacuoles and dilated rough endoplasmic reticulum. To our knowledge, this is the first report of myxoid liposarcoma and leiomyoma co-existing in a canine ovary.

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Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26522811/