Peer-reviewed veterinary case report
Predicting spread of dog mammary tumors by gene test
By Lamp, O et al.·Published in Veterinary and comparative oncology·2013·Institute of Physiological Chemistry, Germany·View original on PubMed →
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Original publication title: The metastatic potential of canine mammary tumours can be assessed by mRNA expression analysis of connective tissue modulators.
- Species:
- dog
Plain-English summary
A study looked at 59 female dogs with mammary tumors to understand how certain proteins might indicate if the cancer could spread. They found that high levels of a protein called RXFP1 were linked to a greater risk of the cancer spreading and shorter survival times. Although the levels of relaxin and its receptor didn't help predict outcomes, RXFP1 could be a useful marker for assessing the severity of the disease. This information could help veterinarians identify which tumors are more aggressive and may need more intensive treatment.
People also search for: dog mammary tumor prognosis · canine cancer spread signs · RXFP1 in dog tumors
Abstract
Metastases are the crucial factor for the prognosis of canine mammary tumours (CMTs). In women, the peptide hormone relaxin is linked with metastatic breast cancer. Therefore, the impact of relaxin and its receptors on matrix metalloproteinase (MMP) expression, metastatic disease and survival was analysed using qRT-PCR and immunohistochemistry of CMT samples from 59 bitches. The expression of relaxin and its receptor RXFP1 (relaxin family peptide receptor 1) was discovered on gene and protein levels. Intratumoural relaxin mRNA expression and relaxin plasma levels had no prognostic value. High mRNA levels RXFP1 were an independent marker of metastatic potential, with a more than 15-fold risk increase, and a predictor for shorter survival. Also, MMP-2 expression was associated with early death because of CMT. The mRNA expressions of relaxin, RXFP1 and MMP-2 were positively correlated indicating a common pathogenetic linkage. Thus, RXFP1 is proposed as a new early marker of metastatic potential in CMT and a possible therapeutic target.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22235833/