Peer-reviewed veterinary case report
Tumour size linked to prognosis markers in female dog mammary tumors
By Ferreira, E et al.·Published in Veterinary and comparative oncology·2009·Department of General Pathology, Brazil·View original on PubMed →
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Original publication title: The relationship between tumour size and expression of prognostic markers in benign and malignant canine mammary tumours.
- Species:
- dog
Plain-English summary
A group of 120 female dogs with mammary tumors were studied to see how tumor size affected their prognosis. It was found that larger tumors were more likely to be malignant and associated with a shorter survival time. Additionally, these larger tumors showed lower levels of progesterone receptors and higher levels of markers related to cell growth. This research emphasizes that the size of a mammary tumor can be an important factor in determining the outcome for female dogs with these types of tumors.
People also search for: dog mammary tumor size prognosis · female dog breast cancer treatment · canine mammary tumor survival rate
Abstract
Tumour size is considered one of the most important determinants of clinical staging in cancer patients. The aim of this study was to assess the value of tumour size as an indicator of the differentiation of mammary neoplasias in female dogs. The tumour, nodes metastates (TNM) system, based on primary lesion size, the extent of its dissemination to regional lymph nodes and the presence or absence of distant metastases, was applied to 120 female dogs diagnosed with mammary neoplasias. Paraffin blocks from 38 cases were selected and studied by immunohistochemical staining for prognostic and predictive markers of breast cancer. The Kaplan-Meier survival curve was estimated for 110 female dogs. Larger tumours (T3) were mostly malignant and showed lower expression of progesterone receptor and higher expression of cellular proliferation markers. Global survival time was shorter in female dogs with large tumour masses. This study highlights the importance of tumour size as a prognostic indicator of mammary neoplasias in female dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19891693/