Peer-reviewed veterinary case report
Cox-2 levels linked to survival in dogs with malignant mammary tumors
By Queiroga, Felisbina L et al.·Published in Research in veterinary science·2010·Department of Veterinary Sciences·View original on PubMed →
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Original publication title: The role of Cox-2 expression in the prognosis of dogs with malignant mammary tumours.
- Species:
- dog
Plain-English summary
A group of 27 female dogs with malignant mammary tumors were studied to see how the presence of a specific enzyme (Cox-2) might affect their prognosis. The results showed that dogs with higher levels of Cox-2 had a greater chance of lymph node metastasis and a shorter time before the disease progressed or recurred. While Cox-2 levels were linked to poorer outcomes, it wasn't a strong enough factor on its own to predict survival. The researchers suggest that using Cox-2 inhibitors could be a helpful part of treatment for these dogs.
People also search for: dog mammary tumor prognosis · Cox-2 inhibitors for dogs · malignant mammary tumors in dogs treatment
Abstract
Immunohistochemical detection of Cyclooxygenase (Cox)-1 and -2 enzymes in canine mammary tumours (CMT) has recently been described. However, the prognostic value of their expression needs to be established. The aim of this study was to investigate Cox (-1 and -2) prognostic value in malignant CMT by evaluating its correlation with clinicopathological parameters (tumour size, histological type, necrosis, lymph node metastasis) and with Disease Free Survival (DFS) and Overall Survival (OS). Twenty seven female dogs with malignant tumours were included. Cox-2 expression was associated with lymph node metastasis at surgery time, development of distant metastasis during follow-up (p=0.038), DFS (p=0.03) and OS (p=0.04). Multivariate survival analysis showed that Cox-2 did not retain its significance as an independent prognostic factor. For Cox-1 expression, no statistically significant association was observed. Present study suggests the usefulness of testing Cox-2 specific inhibitors as part of an adjuvant therapy in female dogs with malignant mammary neoplasias.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19939424/