Peer-reviewed veterinary case report
Bezafibrate treatment lowers high fat levels in dogs safely
By De Marco, V et al.·Published in Journal of veterinary internal medicine·2017·University of Santo Amaro, Brazil·View original on PubMed →
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Original publication title: Therapy of Canine Hyperlipidemia with Bezafibrate.
- Species:
- dog
Plain-English summary
A group of 46 dogs, averaging 9 years old, was treated with bezafibrate for high triglycerides and cholesterol levels. After 30 days of treatment, 91% of the dogs had their triglyceride levels return to normal, and two-thirds of those with high cholesterol also improved. The treatment was safe, with no side effects noted, and liver enzyme levels showed improvement. This suggests that bezafibrate can be an effective option for managing high lipid levels in dogs.
People also search for: dog high cholesterol treatment · bezafibrate for dogs · dog triglyceride levels normal range
Abstract
BACKGROUND: Bezafibrate (BZF) is effective in the treatment of hypertriglyceridemia in human patients, but there are no data on its use in dogs. OBJECTIVE: To assess the safety of BZF in hyperlipidemic dogs and its efficacy in decreasing serum triglyceride (TG) and cholesterol (CHO) concentrations. ANIMALS: Forty-six dogs, 26 females and 20 males, mean (±SD) age of 9 (±3) years, with TG ≥150 mg/dL (33 dogs also were hypercholesterolemic [>300 mg/dL]). METHODS: Prospective, uncontrolled clinical trial. Dogs were treated with bezafibrate once daily, using 200 mg tablets at a dosage of 4-10 mg/kg (depending on body weight). Serum TG and CHO concentrations and alanine aminotransferase (ALT) and creatine kinase (CK) activity before and after 30 days of treatment were compared. RESULTS: Sixteen dogs (34.8%) had primary hyperlipidemia, and 30 dogs (65.2%) had secondary hyperlipidemia (including spontaneous hyperadrenocorticism [41.3%, n = 19/46], chronic treatment with glucocorticoids [10.8%, n = 5/46], and hypothyroidism [15.2%, n = 7/46]). After 30 days, serum TG concentration normalized (<150 mg/dL) in 42 dogs (91.3%) and CHO concentration normalized (<270 mg/dL) in 22 of 33 dogs (66.7%). There was no difference in baseline TG concentration between the primary and secondary hyperlipidemia subgroups, but the decrease in TG concentration after treatment was greater in the primary hyperlipidemia subgroup. No adverse effects were observed, but ALT activity decreased significantly after 30 days of treatment. CONCLUSIONS AND CLINICAL IMPORTANCE: Over 30 days, BZF was safe and effective in treatment of primary and secondary hyperlipidemia in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28382723/