Peer-reviewed veterinary case report
Insulin degludec effects on blood sugar control in diabetic dogs
By Oda, Hitomi et al.·Published in The Journal of veterinary medical science·2018·School of Veterinary Nursing & Technology, Japan·View original on PubMed →
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Original publication title: Time-action profiles of insulin degludec in healthy dogs and its effects on glycemic control in diabetic dogs.
- Species:
- dog
Plain-English summary
A group of diabetic dogs was treated with a new insulin called insulin degludec (IDeg) to see how well it controlled their blood sugar levels. While IDeg helped lower blood glucose, it also caused higher blood sugar levels after meals compared to another insulin type. The study found that IDeg worked for over 20 hours, but it might not be the best option for managing both high blood sugar after eating and low blood sugar before meals at the same time. Pet owners should discuss with their vet whether IDeg is suitable for their diabetic dog.
People also search for: dog diabetes treatment · insulin degludec for dogs · managing dog blood sugar levels
Abstract
Insulin degludec (IDeg) is a new insulin formulation that facilitates long-term control of glucose level in humans. In this study, we investigated the effects of IDeg on glycemic control in dogs. Its time-action profiles were monitored in healthy dogs using an artificial pancreas apparatus under euglycemic conditions. At 9.0-13.5 hr post-IDeg injection, an indistinct peak of glucose level was detected. Moreover, the action of IDeg was persistent for >20 hr. Both IDeg and neutral protamine Hagedorn insulin (NPH) lowered blood glucose concentrations in diabetic dogs, but IDeg caused postprandial hyperglycemia and a somewhat lower preprandial glucose level than that caused by NPH. IDeg might be ineffective in concurrently preventing postprandial hyperglycemia and preprandial hypoglycemia in a single-agent administration.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30305465/