Peer-reviewed veterinary case report
Dog oral papilloma treated with surgery and topical mitomycin C
By Yong, Jungyeon et al.·Published in Veterinary medicine and science·2025·College of Veterinary Medicine, South Korea·View original on PubMed →
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Original publication title: Topical Mitomycin C Application Following Surgical Excision in Canine Oral Papilloma: A Case Report.
- Species:
- dog
Plain-English summary
A 1-year-old German Shepherd was brought in for severe oral papillomas, which are benign growths caused by a virus that can affect young dogs. Previous treatments hadn't worked, so the veterinarian performed surgery to remove the growths and applied a medication called mitomycin C during and after the procedure. This treatment successfully prevented the papillomas from coming back over the next year. The dog showed no signs of recurrence and was much more comfortable after the treatment.
People also search for: dog oral papilloma treatment · German Shepherd mouth growths · mitomycin C for dogs
Abstract
Canine oral papillomatosis, caused by canine papilloma virus 1, is a benign condition primarily affecting young or immunosuppressed dogs. While most cases regress spontaneously, severe cases often require surgical intervention due to extensive lesions and associated discomforts. However, surgical excision is associated with a high risk of recurrence, necessitating adjuvant therapies. This report presents the case of a 1-year-old German Shepherd with severe oral papilloma unresponsive to prior treatments, managed through surgical excision followed by topical mitomycin C (MMC) application. MMC, applied intraoperatively and during follow-up, effectively prevented recurrence over a 1-year period. This case demonstrates the potential of MMC as an effective adjuvant therapy for severe canine oral papillomatosis, providing a novel approach in veterinary medicine.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40509947/