Peer-reviewed veterinary case report
Intratumoral IL-2 treatment helps shrink transmissible venereal
By Den Otter, Willem et al.·Published in Anticancer research·2015·Department of Urology, Netherlands·View original on PubMed →
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Original publication title: Treatment of transmissible venereal tumors in dogs with intratumoral interleukin-2 (IL-2). A pilot study.
- Species:
- dog
Plain-English summary
A group of 13 dogs with transmissible venereal tumors (TVTs) received intratumoral injections of interleukin-2 (IL-2) to see if it could help shrink their tumors. After three months, two dogs had completely lost their tumors, one dog had a partial reduction, and four dogs showed no change in their tumors. Overall, this treatment was effective for about half of the dogs, and there were no harmful side effects reported.
People also search for: dog transmissible venereal tumor treatment · IL-2 for dog tumors · dog tumor injection therapy
Abstract
AIM: To improve the treatment of transmissible venereal tumors (TVTs) in dogs with intratumoral injections of interleukin-2 (IL-2). PATIENTS AND METHODS: We treated 13 dogs with 18 natural TVTs with IL-2. The tumors were treated with intratumoral application of 2×10(6) units IL-2. RESULTS: Three months after injection of IL-2, the tumors in 2/13 dogs had regressed completely, those in 1/13 had regressed partially, and 4/13 dogs had stable disease. CONCLUSIONS: Local IL-2 treatment of TVT is therapeutically effective, as indicated by complete regression (CR), partial regression (PR) and stable disease (SD) of the tumors of 7 out of 13 dogs. In addition, we observed that the intratumoral treatment with IL-2 did not cause any toxic side-effects.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25667450/