Peer-reviewed veterinary case report
Tumor markers Sialyl Lea and T/Tn in dog mammary tumors
By Nowak, M et al.·Published in Veterinary pathology·2009·Department of Biochemistry·View original on PubMed →
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Original publication title: Tumor-associated carbohydrate antigens: Sialyl Lea and T/Tn antigens in canine mammary tumors.
- Species:
- dog
Plain-English summary
A group of dogs with mammary tumors was studied to understand the presence of certain markers that could help identify if the tumors were cancerous or benign. In this study, 28 dogs with malignant tumors and 14 with benign tumors were examined. The results showed that specific markers, known as T and Tn antigens, were more commonly found in the malignant tumors compared to the benign ones. This suggests that these markers could potentially be used to help diagnose and differentiate between types of mammary tumors in dogs.
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Abstract
Twenty-eight canine mammary tubulopapillary carcinomas and 14 simple adenomas were studied by immunohistochemistry for the expressions of the tumor-associated carbohydrate antigens. Sialyl Le(a) was detected in 71.42% of the malignant and 92.84% of the benign tumors. Staining with anti-T and anti-Tn monoclonal antibodies revealed that 85.70% of the tubulopapillary carcinomas expressed T and Tn antigens. In contrast, 50% of the adenomas did not express T antigen, and 42.85% of them were only weakly stained for this carbohydrate structure. In the case of Tn antigen, the majority (57.14%) of samples was weakly stained, and no binding was observed in 35.71% of the analyzed specimens. Comparison of average values of reaction intensity (IRS) scale for malignant versus benign tumors by the Mann-Whitney U-test revealed a significant relationship between T and Tn antigens expression and type (malignant vs. benign) mammary tumors. Based on the results obtained, it is suggested that each of the studied antigens can be treated as a tumor-associated antigen of canine mammary tumors. However, only the T and Tn antigens seem to be associated with malignant transformation of mammary gland cells and to be of potential value as diagnostic markers.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19261632/