Peer-reviewed veterinary case report
Tumour-associated macrophages linked to invasiveness in dog mammary
By Monteiro, L N et al.·Published in Veterinary journal (London, England : 1997)·2018·Laborató, Brazil·View original on PubMed →
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Original publication title: Tumour-associated macrophages: Relation with progression and invasiveness, and assessment of M1/M2 macrophages in canine mammary tumours.
- Species:
- dog
Plain-English summary
A study looked at the role of certain immune cells called macrophages in mammary tumors from 82 female dogs. It found that higher numbers of these macrophages were linked to more advanced cancer stages, larger tumor sizes, and a worse prognosis. Specifically, malignant tumors had a different type of macrophage compared to benign ones, suggesting that these immune cells change as the cancer becomes more aggressive. This research indicates that monitoring macrophage levels could help predict how serious a dog's mammary tumor might be.
People also search for: dog mammary tumor treatment · signs of cancer in female dogs · canine tumor prognosis
Abstract
Macrophages represent a major component of the overall leucocyte population within neoplasms and are important for tumour behaviour in several cancers in human beings. However, little information regarding their role in canine mammary tumours (CMTs) is available. The aim of this study was to address the potential role of tumour-associated macrophages (TAMs) in CMTs. TAMs in CMTs excised from 82 female dogs were quantified at high power (400× magnification) and categorised as low (≤50) or high (>50) TAM counts. Higher TAM counts were associated with clinical stage (P<0.001), tumour type (P=0.016), tumour size (P=0.013), vascular invasion (P=0.031), lymph node metastasis (P=0.003), high proliferation rates (P=0.009), vascular microdensity (P=0.008), invasive tumour profile (P=0.002) and worse prognosis (P=0.018; hazard ratio=0.283). Almost all macrophages infiltrating malignant tumours with high TAM counts expressed CD206 (macrophage mannose receptor 1), while all benign tumours were infiltrated by macrophages expressing inducible nitric oxide synthase (NOS2), suggesting a phenotypic shift from classically activated macrophage (M1) subpopulations towards alternatively activated macrophage (M2) subpopulations in malignant tumours. A triple staining pattern revealed mixed M1/M2 profiles in some tumours, thus characterising an intermediate state. The results indicate that TAMs are associated with more aggressive types of mammary cancer in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29680383/