Peer-reviewed veterinary case report
No clear link between vaccination and immune polyarthritis in dogs
By Idowu, O A & Heading, K L·Published in The Journal of small animal practice·2018·Melbourne Veterinary Specialist Centre, Australia·View original on PubMed →
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Original publication title: Type 1 immune-mediated polyarthritis in dogs and lack of a temporal relationship to vaccination.
- Species:
- dog
Plain-English summary
A group of dogs diagnosed with type 1 immune-mediated polyarthritis (a condition where the immune system attacks the joints) was studied to see if their symptoms started after recent vaccinations. Out of 39 affected dogs, only four had been vaccinated within 28 days before showing signs of the disease, which was similar to the control group. This suggests that there is no strong link between vaccinations and the onset of this type of arthritis in dogs. More research is needed to confirm these findings, but pet owners can be reassured that recent vaccinations are unlikely to cause this condition.
People also search for: dog arthritis symptoms · immune-mediated polyarthritis in dogs · vaccination side effects in dogs
Abstract
OBJECTIVES: To investigate whether there is a temporal relationship between vaccination and the onset of type 1 immune-mediated polyarthritis in dogs. MATERIALS AND METHODS: Retrospective case-control study: 39 dogs from a referral hospital with a diagnosis of type 1 immune-mediated polyarthritis were age-matched with 78 control dogs with other diagnoses. A temporal association between vaccination and polyarthritis was considered positive if recent vaccination had been performed within 28 days of the onset of clinical signs of immune-mediated polyarthritis. The odds ratio association of recent vaccination with immune-mediated polyarthritis was calculated using matched case-control methods. RESULTS: Of the 39 dogs in the type 1 immune-mediated polyarthritis group, four had been vaccinated within 28 days before onset of clinical signs compared to six dogs in the control group. The odds ratio for a dog developing type 1 immune-mediated polyarthritis if vaccinated within the last 28 days was estimated to be 1·44 (95% confidence interval 0·25 to 8·24, P = 0·88). CLINICAL SIGNIFICANCE: There was no evidence of a temporal relationship between vaccination and type 1 immune-mediated polyarthritis, although the large confidence interval on the odds ratio suggests a need for larger studies to confirm this finding.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29095500/