Peer-reviewed veterinary case report
How trilostane helps treat Cushing's disease in dogs
By Lemetayer, Julie & Blois, Shauna·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2018·Department of Clinical Studies, Canada·View original on PubMed →
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Original publication title: Update on the use of trilostane in dogs.
- Species:
- dog
Plain-English summary
A dog with Cushing's disease (hyperadrenocorticism) was treated with a medication called trilostane, which helps control the overproduction of cortisol. Trilostane has been found to be safe and effective for managing symptoms of this condition, but some issues like high blood pressure and protein in the urine may still occur despite treatment. For better results, giving trilostane in smaller doses every 12 hours could be beneficial for many dogs. Overall, trilostane helps improve the quality of life for dogs suffering from Cushing's disease.
People also search for: dog Cushing's disease treatment · trilostane for dogs · symptoms of hyperadrenocorticism in dogs
Abstract
Many articles published in the past few years have contributed to a better understanding of the use of trilostane in dogs. Trilostane is a competitive inhibitor of 3β-hydroxysteroid dehydrogenase, the enzyme essential for synthesis of cortisol and all other steroids. Trilostane is reported to be safe and effective in the treatment of pituitary-dependent hyperadrenocorticism (HAC), adrenal-dependent HAC, and alopecia X. While trilostane controls most of the clinical signs associated with HAC, abnormalities such as hypertension, hypercoagulability, and proteinuria may persist despite therapy. Because the duration of cortisol suppression after a dose of trilostane is often less than 12 hours, many dogs with HAC could benefit from low dose trilostane treatment every 12 hours. Many controversies regarding trilostane still exist. This review provides a comprehensive commentary on trilostane's indications, mode of action, dose, monitoring, efficacy, and adverse effects.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29606727/