Peer-reviewed veterinary case report
Early urine protein test may detect kidney damage in dogs
By Daza, María A et al.·Published in Veterinary parasitology·2024·Veterinary Teaching Hospital, Spain·View original on PubMed →
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Original publication title: Urinary Tamm-Horsfall protein excretion is a potential early biomarker of renal distal tubular damage in canine leishmaniosis.
- Species:
- dog
Plain-English summary
A dog with leishmaniosis (a disease caused by a parasite) may show early signs of kidney damage through changes in their urine. Researchers found that measuring a specific protein in the urine, called Tamm-Horsfall protein, can help identify this damage even before other symptoms appear. By analyzing urine samples, they discovered that dogs with higher levels of protein in their urine might have underlying kidney issues. This test could be useful for vets to catch kidney problems early, allowing for better management and treatment options for affected dogs.
People also search for: dog leishmaniosis kidney damage · Tamm-Horsfall protein test in dogs · early signs of kidney disease in dogs
Abstract
This study evaluates distal tubular damage in early stages of renal disease in dogs with naturally acquired leishmaniosis. Pherograms of urinary proteins separated in vertical electrophoresis system (SDS-PAGE) were evaluated. Peptide fingerprint and fragmentation (MALDI-TOF TOF) identified bands located at 100 and 60 kDa as Tamm-Horsfall protein (THP) and albumin, respectively. The variables examined were: urine protein to creatinine ratio (UPC), total number of bands, quantification of THP urinary excretion through the optical density (OD %) of bands located at 100 kDa, blood creatinine, and urine specific gravity (USG). Positive correlation was found between UPC and the number of bands (ρ = 0.75849, P = <0.0001). Negative correlation was identified between UPC and OD % of 100 kDa bands (ρ = -0.85332, P = <0.0001), and the number of bands and OD % of 100 kDa bands (ρ = -0.74479, P = <0.0001). The area under the ROC curve was 0.991 (95 % CI, 0.976-1). The optimal cut-off UPC that better discriminated between urines with high or low OD% of THP was 0.46 with 92.6 % sensitivity and 96.2 % specificity. Our findings indicate that non azotemic dogs with borderline proteinuria might excrete low amount of THP, which could suggest tubular damage in early stages of chronic kidney disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39094329/