Peer-reviewed veterinary case report
Tumor imaging in two dogs with synovial cell sarcoma using iodine
By Peremans, K et al.·Published in Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·2007·Department of Medical Imaging·View original on PubMed →
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Original publication title: Use of [123I]-2-iodo-L-phenylalanine as a tumor imaging agent in two dogs with synovial cell sarcoma.
- Species:
- dog
Plain-English summary
A 7-year-old mixed-breed dog was diagnosed with synovial cell sarcoma, a type of tumor affecting the joint area. The dog underwent imaging using a special tracer called [123I]-2-iodo-L-phenylalanine, which helped visualize the tumor effectively. The imaging showed good contrast between the tumor and surrounding tissue, allowing for better assessment of the condition. This method could be a promising alternative for identifying tumors in dogs and may also have potential for treatment in the future.
People also search for: dog tumor imaging · synovial cell sarcoma in dogs · treatment for dog tumors
Abstract
[123I]-iodo-L-phenylalanine was successfully evaluated for gamma camera imaging in vivo in tumor-bearing athymic mice and in humans with brain tumors. Here, we report the use of this tracer in two dogs with synovial cell sarcoma of the tarsus. [123I]-iodo-L-phenylalanine was quantitatively prepared as a kit formulation using the Cu(1+) +-assisted nucleophilic exchange. Rapid [123I]-2-iodo-L-phenylalanine tumor accumulation was observed with good tumor to background contrast and rapid clearance in these two dogs. This radiopharmaceutical is a promising alternative tumor tracer to overcome the known limitations of 18F-fluorodeoxyglucose and, when labelled with radioiodine-131, has the potential to be used for therapeutic purposes.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17899985/