Peer-reviewed veterinary case report
Nottingham grading predicts survival in dogs with mammary cancer
By Santos, Marta et al.·Published in Anticancer research·2015·Department of Microscopy·View original on PubMed →
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Original publication title: Value of the Nottingham Histological Grading Parameters and Nottingham Prognostic Index in Canine Mammary Carcinoma.
- Species:
- dog
Plain-English summary
A group of 59 dogs with mammary tumors were studied to see how certain grading systems could predict their outcomes. The research found that dogs with higher grades of tumors, especially grade III, had shorter survival times. A specific feature called nuclear pleomorphism, which looks at the variation in tumor cell nuclei, was linked to poorer survival rates. This means that when a dog is diagnosed with mammary cancer, understanding these grading factors can help veterinarians predict how the disease might progress and tailor treatment accordingly.
People also search for: dog mammary tumor prognosis · canine mammary carcinoma treatment · what does nuclear pleomorphism mean in dogs
Abstract
BACKGROUND/AIM: In the past decade, the human Nottingham histological grade (NHG) has been applied to canine mammary carcinomas (CMC). The Nottingham Prognostic Index (NPI) enables identification of more aggressive human breast cancer. The prognostic value of grading parameters and NPI has never been detailed in CMC. The aim of the present study was to assess the prognostic value of NHG, its parameters and NPI. MATERIALS AND METHODS: Univariable and multivariable analyses were used to assess the prognostic value of NHG, its parameters and NPI in a cohort of 59 dogs with CMC. RESULTS: Short disease-free interval and overall survival were associated with higher NHG, particularly of grade III. Only high nuclear pleomorphism score was significantly associated with poor survival. NPI exhibited a strong predictive value for disease progression. CONCLUSION: NHG, nuclear pleomorphism and NPI have prognostic value in CMC. Nuclear pleomorphism is an independent prognostic factor. Evaluation of nuclear pleomorphism should be included in routine pathology reports.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26124382/