Peer-reviewed veterinary case report
Vitamin D levels in female dogs with mammary tumors
By Pineda, Carmen et al.·Published in Journal of veterinary internal medicine·2024·University of Có, Spain·View original on PubMed →
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Original publication title: Vitamin D status in female dogs with mammary gland tumors.
- Species:
- dog
Plain-English summary
Eighty-five female dogs with mammary tumors were studied to see if they had low levels of vitamin D in their blood. The results showed that the vitamin D levels in these dogs were similar to those in healthy dogs, meaning that low vitamin D is not a factor in developing these tumors. Additionally, the dogs with tumors had higher levels of parathyroid hormone, which is linked to calcium regulation in the body. This suggests that giving vitamin D supplements is not likely to help prevent mammary tumors in female dogs.
People also search for: dog mammary tumor treatment · vitamin D for dogs with tumors · female dog cancer prevention
Abstract
BACKGROUND: Little information exists about vitamin D status in bitches with mammary tumors. OBJECTIVES: To determine whether low plasma vitamin D concentrations are found in bitches with mammary tumors. ANIMALS: Eighty-five client-owned bitches with mammary tumors (n = 21 benign, n = 64 malignant) and 39 age-matched healthy bitches. METHODS: Case-control study. Plasma ionized and total calcium, phosphorus, magnesium, urea, creatinine, albumin, total proteins, alanine aminotransferase, alkaline phosphatase, parathyroid hormone (PTH), calcitriol (1,25-dihydroxyvitamin D), and 25-hydroxyvitamin D concentrations were measured in all bitches at the time of clinical diagnosis and before any treatments. Statistical analysis was performed to compare variables among groups (control, benign, and malignant). RESULTS: No significant differences were found when plasma 25-hydroxyvitamin D concentrations in bitches with malignant (148.9 [59.9] ng/mL) and benign mammary tumors (150.1 [122.3] ng/mL) were compared with control group (129.9 [54.5] ng/mL). Parathyroid hormone was significantly higher in bitches with malignant (19.9 [20.5] pg/mL), and benign mammary tumors (14.6 [14.9] pg/mL) compared with control group (7.5 [7.5] pg/mL; P < .01). Only the presence of mammary tumors (P < .01) and age (P = .04; adjusted R = .22) was significant in predicting PTH. CONCLUSIONS: Bitches with mammary tumors do not have low 25-hydroxyvitamin D concentrations thus vitamin D supplementation is unlikely to be useful for prevention of mammary tumors in bitches.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38946311/