Peer-reviewed veterinary case report
Dog with rare pituitary tumor and typical Cushing's disease symptoms
By Fernández-Gallego, Ana et al.·Published in Journal of comparative pathology·2020·Royal (Dick) School of Veterinary Studies, United Kingdom·View original on PubMed →
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Original publication title: Xanthogranulomatous Pituitary Adenoma in a Dog with Typical Hyperadrenocorticism.
- Species:
- dog
Plain-English summary
A 7-year-old male neutered Labrador Retriever was brought in for worsening lethargy, vomiting, and decreased appetite. He had a history of chronic kidney disease and other hormonal issues. Despite medical treatment, his condition did not improve, and he was euthanized. A post-mortem examination revealed a rare condition called xanthogranulomatous pituitary adenoma, which may have contributed to his symptoms.
People also search for: dog vomiting lethargy · Labrador Retriever kidney disease · pituitary problems in dogs
Abstract
Xanthogranuloma of the sellar region has been reported in both humans and animals. The lesion is rare, and its aetiology and pathogenesis are not fully understood. The association of sellar xanthogranuloma with an adenoma, known as xanthogranulomatous pituitary adenoma (XPA), is an extremely rare condition in humans and is usually associated with anterior pituitary insufficiencies, headache, vomiting and visual deficits. We present the first report of XPA in an animal. A 7-year-old male neutered Labrador Retriever was presented for investigation of progressive lethargy, vomiting and hyporexia, having been previously diagnosed with chronic kidney disease, pituitary-dependent hyperadrenocorticism and hypoparathyroidism. The dog was euthanized due to lack of response to medical treatment and post-mortem examination revealed XPA. Although rare, xanthogranulomatous lesions should be considered in patients with pituitary disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33222868/