Peer-reviewed veterinary case report
Adverse reactions to trimethoprim-sulphonamide in dogs and cats
By Noli, C et al.·Published in The veterinary quarterly·1995·Faculty of Veterinary Medicine, Netherlands·View original on PubMed →
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Original publication title: A retrospective evaluation of adverse reactions to trimethoprim-sulphonamide combinations in dogs and cats.
Plain-English summary
A group of 19 dogs and 2 cats experienced adverse reactions after being treated with trimethoprim-sulphonamide combinations, a type of antibiotic. Symptoms included serious skin issues like toxic epidermal necrolysis and erythema multiforme, which appeared within 7 to 14 days of starting the medication. The most common cause of these reactions was found to be sulphadiazine. Fortunately, with proper veterinary care, many pets can recover from these reactions, but it's essential to monitor for any unusual symptoms after starting new medications.
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Abstract
Adverse reactions to various trimethoprim-sulphonamide (T-S) combinations were studied retrospectively in dogs and cats referred to the Utrecht University Department of Clinical Sciences of Companion Animals during the period 1985-1994. Dermatological and systemic reactions were observed in 19 dogs and 2 cats. Specific histological reaction patterns were seen in 3 dogs with toxic epidermal necrolysis, in 1 dog and 1 cat with erythema multiforme, and in 1 dog with pemphigus foliaceus. Diagnostic criteria used in humans proved to be reliable in dogs and cats as well. Adverse reactions were observed within 7-14 days after administration and were most often due to sulphadiazine (76%) and sulphatroxazole (14%). The incidence of adverse reactions to T-S was 0.25%.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8751272/