Peer-reviewed veterinary case report
A retrospective evaluation of adverse reactions to trimethoprim-sulphonamide combinations in dogs and cats.
- Journal:
- The veterinary quarterly
- Year:
- 1995
- Authors:
- Noli, C et al.
- Affiliation:
- Faculty of Veterinary Medicine · Netherlands
Plain-English summary
Researchers looked at how dogs and cats reacted to a combination of medications called trimethoprim-sulphonamide (T-S) over a period from 1985 to 1994. They found that 19 dogs and 2 cats had negative reactions, which included skin issues and other systemic problems. Some specific skin conditions were identified, such as toxic epidermal necrolysis in three dogs and erythema multiforme in one dog and one cat. Most reactions happened within one to two weeks after starting the medication, with the majority linked to a specific ingredient called sulphadiazine. Overall, the study found that adverse reactions to these medications were relatively rare, occurring in about 0.25% of cases.
Abstract
Adverse reactions to various trimethoprim-sulphonamide (T-S) combinations were studied retrospectively in dogs and cats referred to the Utrecht University Department of Clinical Sciences of Companion Animals during the period 1985-1994. Dermatological and systemic reactions were observed in 19 dogs and 2 cats. Specific histological reaction patterns were seen in 3 dogs with toxic epidermal necrolysis, in 1 dog and 1 cat with erythema multiforme, and in 1 dog with pemphigus foliaceus. Diagnostic criteria used in humans proved to be reliable in dogs and cats as well. Adverse reactions were observed within 7-14 days after administration and were most often due to sulphadiazine (76%) and sulphatroxazole (14%). The incidence of adverse reactions to T-S was 0.25%.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/8751272/