Peer-reviewed veterinary case report
Acetylcholinesterase levels in cerebrospinal fluid of dogs
By Chai, Orit et al.·Published in Veterinary journal (London, England : 1997)·2013·Koret School of Veterinary Medicine·View original on PubMed →
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Original publication title: Acetylcholinesterase activity in the cerebrospinal fluid of dogs with seizures.
- Species:
- dog
Plain-English summary
A group of dogs that had seizures was tested to see if certain enzymes in their spinal fluid could provide clues about their condition. Researchers compared these dogs to others with back problems and healthy dogs, but they found no significant differences in the enzyme levels among the groups. This means that measuring these enzymes in the spinal fluid may not be helpful for understanding seizures in dogs. More research is needed to explore other potential causes and treatments for seizures.
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Abstract
Recent studies in animal models have focused on the role of cholinergic elements, mainly acetylcholinesterase (AChE) and the 'readthrough' acetylcholinesterase isoform (AChE-R), in seizures. A prospective double-masked study was conducted to assess the activity of AChE and AChE-R in cerebrospinal fluid (CSF) of 26 dogs post-seizure, 28 dogs with intervertebral disc disease (IVDD) and 16 healthy dogs. AChE was also measured in the serum in the post-seizure and IVDD groups. The results showed no significant differences in CSF AChE among the three groups. AChE-R was not detected in any dog and AChE in the serum was similar between groups. This preliminary study provides new information on AChE and AChE-R in the CSF and sera of dogs following naturally-occurring seizures.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23988333/