Peer-reviewed veterinary case report
Ameloblastic carcinoma in a horse.
- Journal:
- Journal of comparative pathology
- Year:
- 2003
- Authors:
- De Cock, H E V et al.
- Affiliation:
- Department of Pathology · United States
- Species:
- horse
Plain-English summary
A 30-year-old Quarter Horse mare was diagnosed with a type of cancer called ameloblastic carcinoma, which is a fast-growing and destructive tumor. The tumor was found to be invasive, meaning it spread into surrounding tissues. When examined under a microscope, the tumor showed a mix of different cell shapes and patterns, which is typical for this kind of cancer. Special tests confirmed the presence of certain proteins that are associated with this type of tumor, supporting the diagnosis. Overall, the findings indicate that the mare has a serious condition that requires careful management.
Abstract
The clinical, gross morphological, histological and immunohistochemical characteristics of an ameloblastic carcinoma in a 30-year-old Quarter Horse mare are reported. This tumour was fast growing, locally invasive and destructive. Histologically, it showed an infiltrative pattern of large islands, broad sheets and, at the periphery, small cords of moderately pleomorphic round, oval to spindle-shaped cells. Immunohistochemical evaluation revealed positive labelling for vimentin, cytokeratin 5/6 and cytokeratin 14. In the oral cavity of human beings, this immunolabelling pattern is unique for the embryonal enamel organ and tumours of ameloblastomatous epithelial origin, which strongly supports the diagnosis of equine ameloblastic carcinoma.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/12634103/