Peer-reviewed veterinary case report
Immunohistochemical Characteristics of Spindle Cell Ameloblastic Carcinoma in a Horse.
- Journal:
- Journal of comparative pathology
- Year:
- 2022
- Authors:
- Ochi, Akihiro et al.
- Affiliation:
- Equine Research Institute · Japan
- Species:
- horse
Plain-English summary
A 2-year-old male Thoroughbred horse had a large mass in its upper jaw, about 8 centimeters wide, which was causing some of its teeth to shift and break down. The mass was ulcerated and affected the upper left front teeth. A closer examination of the tissue showed that the mass was made up of abnormal cells that had a specific shape and arrangement. These findings led to a diagnosis of spindle cell ameloblastic carcinoma, a type of cancer affecting the cells that form teeth.
Abstract
A 2-year-old male Thoroughbred horse presented with a mass in the maxilla. The focally ulcerated mass, approximately 8 cm in diameter, covered the upper left intermediate and corner incisor teeth (nos. 602 and 603 according to the modified Triadan system) and radiographic examination revealed displacement and lysis of the incisors. Histologically, the tumour was composed of a dense proliferation of spindle-shaped cells and neoplastic odontogenic epithelial cells arranged in island, follicular, plexiform or sheetlike patterns. The spindle-shaped cells were immunopositive for cytokeratins AE1/AE3, 5/6, 14 and 19. The Ki-67 index was 32.6% in the spindle cell component. Based on the histological and immunohistochemical findings, the tumour was diagnosed as spindle cell ameloblastic carcinoma.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/36008038/