Peer-reviewed veterinary case report
Cerebral ganglioneuroblastoma in a golden retriever dog.
- Journal:
- Veterinary pathology
- Year:
- 2004
- Authors:
- Kuwamura, M et al.
- Affiliation:
- Osaka Prefecture University · Japan
- Species:
- dog
Plain-English summary
An 8-month-old Golden Retriever was put to sleep because it had a large tumor in its brain, affecting areas from the right frontal lobe to the thalamus. The tumor was made up of both mature and immature nerve cells, with the more developed cells showing certain characteristics that indicated they were nerve cells, while the less developed ones did not show these signs. This type of tumor, called cerebral ganglioneuroblastoma, is very rare in animals, especially in the brain, and this is the first time it has been reported in a dog. Unfortunately, due to the severity of the condition, the decision was made to euthanize the dog.
Abstract
An 8-month-old Golden Retriever dog was euthanatized because of a large cerebral mass extending from the right frontal lobe to the thalamus that was composed of both mature and immature neuronal cells. The better differentiated cells had abundant eosinophilic cytoplasm with prominent Nissl substance and were generally positive for neurofilament and variably positive for synaptophysin. The generally smaller and less-differentiated cells were infrequently positive for proliferating cell nuclear antigen and were negative for any neuronal and glial markers. No apparent glial differentiation of the immature tumor cells was detected. Based on morphologic and immunohistochemical features, the diagnosis of cerebral ganglioneuroblastoma was made. This neoplasm is very rare in all species, especially in the central nervous system, and has never been reported previously in this site in a dog.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15133180/