Peer-reviewed veterinary case report
How Cushing's syndrome affects kidney function in dogs
By Smets, P M Y et al.·Published in Veterinary journal (London, England : 1997)·2012·Department of Small Animal Medicine and Clinical Biology·View original on PubMed →
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Original publication title: Hypercortisolism affects glomerular and tubular function in dogs.
- Species:
- dog
Plain-English summary
A group of 25 dogs with Cushing's syndrome (a condition caused by excess cortisol) had their kidney function tested and showed some concerning changes compared to 12 healthy dogs. The tests revealed that while some kidney markers were normal, others indicated that both parts of the kidneys were not working as well as they should. This means that dogs with Cushing's syndrome might face kidney issues that could affect their overall health. If your dog has Cushing's, it’s important to monitor their kidney function regularly with your vet.
People also search for: dog Cushing's syndrome kidney problems · symptoms of kidney disease in dogs · how does Cushing's affect dogs' health
Abstract
Renal function was assessed in 25 dogs with Cushing's syndrome and in 12 healthy controls. Routine renal parameters and glomerular filtration rate (GFR) were measured and urinary biomarkers such as urinary albumin (uALB), urinary immunoglobulin G (uIgG), and urinary retinol-binding protein (uRBP) were assessed by ELISA. Urinary N-acetyl-β-D-glucosaminidase activity (uNAG) was determined colorimetrically. All urinary markers were indexed to urinary creatinine concentration (c). Plasma exo- (Cl(exo)) and endo-iohexol (Cl(endo)) clearance were used to measure GFR. Based on a Mann-Whitney U test, urea and Cl(exo) did not differ, sCr was significantly lower, and UPC, uALB/c, uIgG/c, uRBP/c, uNAG/c and Cl(endo) were higher in the dogs with Cushing's syndrome when compared with controls. The findings indicate that glomerular and tubular function are both altered in dogs with Cushing's syndrome. Further longitudinal studies will be required to elucidate the pathogenesis of the changes in GFR.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21723755/