Peer-reviewed veterinary case report
Dog with lymphoma and widespread skin thickening from cancer-related
By V. Affolter et al.·Published in Veterinary dermatology (Print)·2020·View original on Semantic Scholar →
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Original publication title: Multicentric B-cell lymphoma with presumed paraneoplastic generalized cutaneous sclerosis in a dog.
- Species:
- dog
Plain-English summary
A 12-year-old male chihuahua-mix was brought to the vet for skin problems, including severe hair loss and thickened skin, along with swollen lymph nodes. Tests revealed that he had an intermediate to large B-cell lymphoma, a type of cancer. Although the lymphoma was treated, the skin issues did not improve, and sadly, the dog was euthanized. This case highlights a rare connection between lymphoma and skin thickening in dogs.
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Abstract
BACKGROUND Reports of dermal sclerosis in dogs include scleroderma or morphea of unknown cause, cicatricial alopecia and congenital/hereditary fibrosis. CLINICAL SUMMARY A 12-year-old, male castrated chihuahua-mix dog was evaluated for skin lesions of unknown duration. The dog had severe alopecia, skin thickening and marked peripheral lymphadenopathy. Lymph node cytological investigation, immunohistochemical investigation and clonality testing demonstrated an intermediate to large B-cell lymphoma. The thickened skin had severe collagen deposition, effacing adnexal structures. The dog's lymphoma was treated but the skin lesions remained unchanged. The dog was euthanized. CONCLUSIONS AND CLINICAL IMPORTANCE To the best of the authors' knowledge, this is the first report of multicentric B-cell lymphoma in a dog with concurrent diffuse cutaneous sclerosis, similar to a human paraneoplastic reaction.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/31930629