Peer-reviewed veterinary case report
Early osteoarthritis detection in young dogs with hip dysplasia using
By Kataru,, Jagan Mohan Reddy et al.·Published in Indian Journal of Animal Research·2023·View original on Crossref →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Serum Hyaluronic Acid- An Effective Biomarker for Early Detection of Osteoarthritis in Young Dogs with Canine Hip Dysplasia
- Species:
- dog
Plain-English summary
A group of young dogs with hip dysplasia (a common joint problem) had their blood tested for a substance called hyaluronic acid (HA) to see if it could help detect early signs of osteoarthritis. The results showed that dogs with hip dysplasia had lower levels of HA compared to healthy dogs of the same age. This suggests that measuring HA levels in the blood could be a useful way for vets to identify early joint issues in young dogs. Early detection can lead to better management and treatment options for dogs at risk of developing osteoarthritis.
People also search for: dog hip dysplasia symptoms · young dog osteoarthritis treatment · hyaluronic acid for dogs arthritis
Abstract
Background: Most of the biomarkers used in joint disease are articular cartilage components such as chondroitin sulphate (CS), keratan sulphate (KS), hyaluronic acid (HA), or type II collagen. Some of these biomarkers, alone or together, could have the potential to provide clinically useful indices of the effects of isolated joint injury, the progression of joint changes and/or the response to therapy. Serum concentration of HA were elevated in human patients with osteoarthritis which increase is considered a reliable biomarker reflective of cartilage damage and synovitis in these patients. Methods: Blood samples were collected from all the dogs and serum concentration of hyaluronic acid was determined by Canine Hyaluronic Acid Elisa kit (catalogue No.ITE070452), SIZE -96T, Reactivity: Canine, Range: 2 ng/ml -700ng/ml and sensitivity: 1.04 ng/ml, supplied by G Biosciences. Result: Serum concentration of HA were lower in dogs aged between 0 to 12 months with CHD when compared to dogs of similar age with healthy hip joints and that this significant decrease in serum HA in dogs can be considered a reliable biomarker reflective of CHD and serum HA levels can be used as an effective biomarker for osteoarthritis in dogs with CHD.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on Crossref: https://doi.org/10.18805/ijar.b-5054