Peer-reviewed veterinary case report
Subcutaneous nerve sheath tumor with gland-like features in a German
By Volmer, Christelle et al.·Published in The Journal of veterinary medical science·2010·Department of Pathology, France·View original on PubMed →
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Original publication title: An atypical peripheral nerve sheath tumour with pseudoglandular architecture in a dog.
- Species:
- dog
Plain-English summary
A 5-year-old German Shepherd was found to have a soft tissue tumor under the skin. The tumor was made up of abnormal cells that formed structures resembling glands, which is unusual for this type of tumor. After testing, it was diagnosed as a peripheral nerve sheath tumor (PNST). This case highlights the different appearances these tumors can have and helps veterinarians differentiate them from other skin tumors.
People also search for: dog skin tumor symptoms · German Shepherd tumor treatment · peripheral nerve sheath tumor in dogs
Abstract
This case describes a subcutaneous soft tissue tumour in a German Shepherd dog. Histologically, the lesion was characterized by proliferating ovoid cells, loosely arranged in a collagenous to myxoid stroma, and by numerous pseudoglandular structures lined by neoplastic cells. Immunohistochemically, neoplastic cells were labelled with vimentin, glial fibrillary acidic protein and S100 antibodies, but not with cytokeratin, desmin and smooth muscle actin antibodies. Ultrastructurally, neoplastic cells were characterized by numerous mitochondria surrounded by endoplasmic reticulum and contained few secondary lysosomes. This tumour was diagnosed as a subcutaneous peripheral nerve sheath tumour (PNST) with pseudoglandular architecture. This case illustrates the morphological diversity of PNST and provides new insight into the differential diagnosis of cutaneous tumours of similar morphology in the dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19942806/